A Three‐Way Regioselective Synthesis of Amino Acid Decorated Imidazole, Purine and Pyrimidine Derivatives by Multicomponent Chemistry Starting from Prebiotic Diaminomaleonitrile

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the pyrimidine and purine ribonucleotides; no divergent synthesis from common precursors has been proposed. Moreover, the prebiotic syntheses of pyrimi...

Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases and phosphorylated carbohydrates.

According to a current "RNA first" model for the origin of life, RNA emerged in some form on early Earth to become the first biopolymer to support Darwinism here. Threose nucleic acid (TNA) and other polyelectrolytes are also considered as the possible first Darwinian biopolymer(s). This model is being developed by research pursuing a "Discontinuous Synthesis Model" (DSM) for the formation of R...

Prebiotic Synthesis of Pyrimidine Nucleosides

A Sustainable Multicomponent Pyrimidine Synthesis.

Since alcohols are accessible from indigestible biomass (lignocellulose), the development of novel preferentially catalytic reactions in which alcohols are converted into important classes of fine chemicals is a central topic of sustainable synthesis. Multicomponent reactions are especially attractive in organic chemistry as they allow the synthesis of large libraries of diversely functionalize...

Pyrimidine Derivatives and Purine Bases in Soils

In earlier papers the presence of protein decomposition products in soils was reported and it was shown that in soils the changes occurring in the decay of such plant and animal materials as get into the soil are similar to the changes occuring under other conditions in the laboratory or in nature. The presence of arginine and histidine in soils was definitely established by isolating these deg...